ASCEplus exosomes in scar therapy – a review of the latest research

Facial surgical procedures such as facelifts and blepharoplasty offer patients spectacular aesthetic results. Increasingly, however, expectations extend beyond improving facial contours, skin firmness, and wrinkle reduction, to rapid healing and minimizing visible scarring. 

The early phase of tissue regeneration is crucial in this process – it is here that the decision is made whether the scar will be subtle and well-integrated with the surroundings, or whether it will become a permanent mark after the procedure.

Latest publications in the journal Pharmaceuticals Authored by Lidia Majewska, MD, PhD, Agnieszka Kondraciuk, MD, Agnieszka Budzyńska, MD, Iwona Paciepnik, and Karolina Dorosz, the study provides significant data on the use of dermal stem cell-derived exosomes (RSCE) in wound healing and scar therapy. This research focuses on the ASCEplus preparation, which, thanks to its high degree of standardization and purity, is characterized by predictable biological activity.

 

Study “Application of Standardized Rosa damascena Stem Cell-Derived Exosomes in DermatologicalWound Healing and Scar Management: A Retrospective Case-Series Study with Long-Term Outcome Assessment” (Pharmaceutics 2025, 17, 910.)

Research "Application of Standardized Rosa damascena Stem Cell-Derived Exosomes in Dermatological Wound Healing and Scar Management” was a retrospective case series and included patients with various types of skin damage – from acute wounds after fresh surgical procedures, through mechanical injuries and burns, to fixed scars, including hypertrophic and atrophic scars. 

In some patients, ASCEplus exosome therapy was initiated immediately after wound closure, allowing for the evaluation of the impact of early intervention on the healing process. In other cases, exosomes were applied to scars that had been present for several months or years to assess their ability to remodel scar tissue.

Analysis of the results showed that the best results were obtained with early implementation of therapy – Wounds healed faster, with reduced inflammation and a reduced risk of excessive connective tissue growth. Scars resulting from this treatment were more elastic, less visible, and better matched in color to the surrounding skin. In older scars, a reduction in their thickness, a smoother surface, and improved skin mobility within the lesion were observed. 

The results showed that early implementation of ASCEplus therapy:

accelerated epithelialization, shortening the time from damage to full epidermal coverage,

reduces redness and swelling, which limited inflammation in the acute phase,

improves skin elasticity and structure, supporting collagen reconstruction,

shortened the time to obtain flat scarsj, well integrated with the surroundings.

The study authors emphasized that standardized ASCEplus exosomes may be a valuable complement to dermatological and surgical therapies, especially in the prevention of hypertrophic scars and in improving the quality of existing scars.

[The full text of the study in English is available at this link]

 

“Exosomes for Advanced Scar Treatment” study (Pharmaceuticals 2025, 18, 1103.)

The "Exosomes for Advanced Scar Treatment" study focuses on the clinical effects of standardized exosomes in the treatment of acute and chronic scars. The authors presented case reports of patients with various types of scars—including post-traumatic, post-burn, and laser-induced—who received ASCEplus therapy early in the healing process or to improve the quality of existing scars. 

Each of the descriptions noted the beneficial effects of RSCE, including faster epithelialization, reduced erythema and swelling, and improved skin elasticity and structure.

The study's conclusions emphasize that The key to achieving the best results is to implement ASCEplus therapy as early as possible, preferably with an intensive local application regimen. This approach limits inflammation, minimizes the risk of excessive fibrosis, and shortens the time required to achieve a flat, well-integrated scar. The authors also point out that exosome therapy can be a valuable complement to surgical and aesthetic medicine procedures, particularly where combining high-quality aesthetic results with a rapid return to daily activities is crucial. 

[The full text of the study in English is available at this link]

 

Exosomes in plastic surgery 

Both studies indicate that ASCEplus could become an important component of treatment protocols in plastic, reconstructive, and dermatological surgery. Of particular importance is:

– starting therapy as early as possible,
– use of an intensive local application regimen in the proliferation phase,

– continuation of therapy in the scar remodeling phase to achieve optimal results.

 

In the context of the growing number of aesthetic procedures, ASCEplus exosomes offer physicians a tool that allows them not only to improve the aesthetic effect of the procedure, but also to significantly influence patient comfort and satisfaction. 

 

Scar Reduction – Scar Reduction with Exosomes

Exosomes ASCEplus They are finding increasing use in modern treatments for fresh scars, both after surgical procedures and skin injuries. Thanks to their high content of growth factors and signaling proteins, they regulate repair processes, limiting excessive scarring. They stimulate proper collagen remodeling, improve skin elasticity and tone at the healing site, and shorten tissue regeneration time. Incorporating exosomes into therapy in the early stages of healing can significantly reduce the visibility of scars, resulting in improved aesthetic outcomes and greater patient comfort.

ASCEplus exosomes in the treatment of fresh scars after surgical procedures

Clinical studies confirm that the use of exosomes in the treatment of fresh scars after procedures such as facelifts or blepharoplasty allows for improved aesthetic results and shorter recovery times. Their inclusion in post-procedure protocols could become a standard in modern aesthetic surgery, ensuring patients a faster return to daily life and greater satisfaction with the results.

Scars after eyelid surgery – how to reduce their visibility

Similarly, in the case of treatments such as eyelid surgery, where scars are located in the highly visible eye area, the aesthetics of their healing are crucial. Exosomes ASCEplus They have regenerative and anti-inflammatory properties, helping to even out skin tone, reduce redness, and improve elasticity at the surgical site. This can make eyelid surgery scars less visible in a shorter time, which is especially important in this delicate area of the face.